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Vertex Ventures HC
Vertex Ventures HC

Head of Global Medical Affairs

Bicycle Therapeutics

Bicycle Therapeutics

Cambridge, MA, USA
Posted on Friday, May 31, 2024

Company Description

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

  • We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.

  • We are Dedicated to our Mission. You can’t change the world if you don’t have determination.

  • We are One Team. We only succeed when we work together.

Job Description

The Head of Global Medical Affairs will provide strategic leadership to develop an integrated medical affairs strategy with a significant impact on Bicycle’s current and emerging programs. You will actively support clinical development activities, operating cross-functionally by engaging with the diverse teams across Bicycle including, but not limited to: Research, Clinical, Regulatory Affairs, Commercial, and other functions, to ensure that scientific and medical strategies are aligned with corporate and medical community needs. Key contributor to new product planning and pre-launch activities.

  • Develop the global Medical Affairs function, building and developing a global team (including a field MSL team) as we prepare for commercialization
  • Develop the Medical Affairs strategy and operational plan in a cross functional manner including contributions to Bicycle Corporate Goals
  • Lead internal data interpretation, analysis plans and communication strategy
  • Lead publication strategy and planning for Bicycle, define publication timelines, and review all publications (abstracts, manuscripts, posters, presentations, etc.) and ensure that they are consistent with the strategy
  • Responsible for, in conjunction with the Clinical Development team, ensuring the successful dissemination of innovative clinical information to thought leaders and foster medical and scientific information exchange
  • Work closely with healthcare practitioners and KOLs for their valuable input, organization/facilitation of advisory boards in coordination with clinical development
  • Proactively incorporate patients' & physicians' voice in the development of medical strategies & tactics
  • Prioritize relationships with key access decision-makers in healthcare systems, managed care organizations, payers, and government programs
  • Develops and maintains positive professional relationships with thought-leaders based on mutual respect and the interest in sharing perspective on medical therapies. This includes obtaining feedback from the independent community of relevant healthcare professionals within Oncology globally
  • Management of investigator supported trials when programs are initiated
  • Strategic development of Medical Information content and services (including standard responses, FAQs and medical library), including the management and training of staff and/or vendors as we approach commercialization
  • Key contributor to new product development / planning and pre-launch activities


  • Degree preferred - MD, PharmD or PhD
  • Significant Medical Affairs experience within the biopharmaceutical industry
  • Clinical experience in oncology strongly preferred
  • Solid working knowledge of the regulatory and compliance environment
  • Strong people leader with a track record in building highly engaged and high performing teams
  • Ability to create progressive medical affairs strategies and execute deliverables
  • Excellent strategic thinking skills, with demonstrated ability to successfully lead the ideation and development of a plan and move to action
  • Possess a willingness and ability to work hands-on and with a sense of urgency, in a fast-paced, entrepreneurial environment
  • Existing relationships with oncology institutions strongly preferred
  • Outstanding written and verbal communication skills with the ability to effectively present to and engage with a wide range of audiences

Additional Information

  • Flexible working environment
  • Competitive reward including annual company bonus
  • Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
  • Health and Dependent Care Flexible Spending Accounts
  • 401(k) plan with a 4% Company match and immediate vesting
  • Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
  • Employee assistance program
  • Employee recognition schemes
  • 10 Company holidays
  • Competitive Family Leave Policy
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.