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Vertex Ventures HC
Vertex Ventures HC

Director, Thought Leader Engagement

Bicycle Therapeutics

Bicycle Therapeutics

Cambridge, MA, USA
Posted on Sunday, June 9, 2024

Company Description

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

  • We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
  • We are Dedicated to our Mission. You can't change the world if you don't have determination
  • We are One Team. We only succeed when we work together.

Job Description

We have an exciting and new opportunity for an experienced Director, Thought Leader Engagement to join the Bicycle team, reporting into the Senior Director, Customer Engagement.

You will be responsible for gathering key insights and evolving sentiment for Bicycle’s US Oncology portfolio with National/Regional Key Opinion Leaders (KOLs), Medical Experts (MEs), promotional speakers and other key influencers in the US. This critical role will work closely with members of the Bicycle commercial teams. You will be responsible for working cross-functionally with US Marketing, Medical Affairs, Global Marketing, Market Access and eventually Sales to shape and develop customer engagement strategies, execute prioritized tactics, generate actionable insights, address customer needs, anticipate market trends and uncover competitive intelligence, ensuring delivery against business objectives in alignment with commercialization business partners.

As a newly created position, you will have the opportunity, within a small team of their peers, to establish the Key Opinion Leader commercial strategy from Bicycle’s first US based launch through a rapid succession of potential follow-on indications and maturing pipeline of innovative brands. Success in this role will require a collaborative mindset, oncology (w/ recent launch) experience, and a proven track record operating in an emerging/developing organization.

This will be a hands-on role as functions are onboarded and require domestic travel as needed.

Key responsibilities

  • Represent Bicycle interests as the primary point of contact with Key Opinion Leaders (KOLs) and Medical Experts (MEs) relevant to the commercial business.
  • Effectively communicate complex scientific knowledge as it pertains to customer engagement, brand strategies and prioritized tactics.
  • Effectively translate primary & secondary data into insights and actionable commercial strategies and tactics.
  • Appropriately and compliantly integrate professional promotion strategies into the Thought Leader Engagement strategic plan.
  • Lead management (e.g., orchestrating KOL engagement planning, insight generation, and facilitate logistics) of commercial advisory boards, speaker bureau, conventions and congresses.
  • Partner with Marketing and all Bicycle field facing roles to establish the appropriate metrics (quantitative and qualitative) and track performance.
  • Track and provide quarterly reports on performance to commercial team and the executive leadership team.
  • Work effectively with Bicycle sales leadership (and field sales teams), relevant Bicycle functions, and commercialization partners.
  • Manage project timelines, and budgets.
  • Pull through the vision set by the Senior Director, Head of Customer Engagement.


  • Extensive experience in Hematology/Oncology sales, marketing and/or account management or experience within a high science TA; previous Thought Leader Liaison experience desirable.
  • Educated within relevant subject matters or equivalent career experience.
  • Recent launch experience strongly preferred.
  • Experience working in the highly complex, dynamic environment of an emerging organization; direct startup, or new team experience desired.
  • Ability to work cross-functionally and on multiple projects simultaneously.
  • Ability to thrive in ambiguity, with an entrepreneurial mindset and a track record of high-performance results.
  • Resourceful, decisive, and proactive approach to managing multiple priorities in a fast-growing organization.
  • Strong communication and presentation skills.
  • Ability to travel domestically as needed, in addition to some weekends in accordance with all Bicycle established safety and travel policies.

Additional Information

  • Flexible working environment
  • Competitive reward including annual company bonus
  • Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
  • Health and Dependent Care Flexible Spending Accounts
  • 401(k) plan with a 4% Company match and immediate vesting
  • Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
  • Employee assistance program
  • Employee recognition schemes
  • 10 Company holidays
  • Competitive Family Leave Policy
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.