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Vertex Ventures HC
Vertex Ventures HC

Principal Developer

Bicycle Therapeutics

Bicycle Therapeutics

Software Engineering
Cambridge, UK
Posted on Thursday, June 13, 2024

Company Description

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

  • We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
  • We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
  • We are One Team. We only succeed when we work together.

Job Description

As our team expands, we have created an exciting new opportunity for a Principal Developer at Bicycle Therapeutics’ offices at Granta Park, Cambridge.

We are looking for a proactive, highly motivated and ambitious developer, with significant experience developing innovative front-end interfaces and back-end services. You are someone who wants to challenge their skills, is a self-starter, is comfortable at working independently as well as across functions in the UK & US. Our function’s core principle is to do the hard work to make things simpler for our users.

The goal of this role is to rapidly develop MVP prototypes, design dynamic user-interfaces, and collaborate with stakeholders to deliver apps that will allow all business departments to explore data visually, and make data-driven decisions. You will have demonstrable experience in front-end development (JavaScript), experience in back-end Frameworks (Flask, Django), database technologies (SQL, no-SQL), software engineering best practices (CI-CD, Agile, Git), and demonstrable experience of building systems in GCP / AWS / Azure. Ultimately you will help to drive the next growth cycle at Bicycle.

Key responsibilities:

  • Rapidly prototype web apps in collaboration with the data science team and end scientist users.
  • Work with the wider technology teams to bring prototypes into production, helping scope whether on-prem v on-cloud (Google Cloud Platform / AWS) would be most suitable.
  • Consume and wrangle data into data stores by implementing analysis workflows.
  • Link data from various sources using APIs.
  • Help develop prototype software for science teams for lab-based equipment.
  • Drive the implementation of best practises for administering and maintaining code development pathways.
  • Work with senior members of the team to survey existing solutions and technologies in order to recommend & implement appropriate technical solutions.
  • Leading the implementation of new data management systems.



  • Demonstrable cloud experience, building systems in AWS / GCP / Azure from scratch.
  • Demonstrable experience working across the stack, from backend systems to front end data visualisation.
  • Experience in implementing tools and processes for automating deployment of services, and ensuring best practices are implemented.
  • Experience with Atlassian Confluence for documentation.
  • Experience with querying API / RESTful interfaces.
  • Experience with SQL/NoSQL database administration (structured / unstructured data).
  • Experience with implementing SSO via Azure / Active Directory.
  • Demonstrable experience with software development best practices (git, CI-CD), agile experience a plus.
  • Experience with Jupyter notebooks/lab and Matlab script development.
  • Experience with containerization, dependency, microservice management (docker, Kubernetes etc).
  • Experience with signal processing and working with data acquisition platforms on Windows.


  • Experience with front end frameworks.
  • Experience with Amazon Web Services.
  • Experience with pipelining tools.
  • Experience of working in GXP environments.
  • Experience working with biological, chemical or drug discovery data a plus.

Additional Information

  • State-of-the-art campus environment with on campus restaurant and Montessori nursery
  • Flexible working environment
  • Competitive reward including annual company bonus
  • Employee recognition schemes
  • 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
  • Employer contribution to pension (employee does not have to contribute)
  • Life assurance cover 4x basic salary
  • Private Medical Insurance, including optical and dental cover
  • Enhanced parental leave policies
  • Group income protection
  • Employee assistance program
  • Health Cash Plan
  • Access to company subsidized gym membership
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.