Company Description

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
• We are One Team. We only succeed when we work together.

Job Description

We are seeking an experienced Program Director with a strong track record of successful project delivery to provide operational leadership of a cross functional global program team (GPT) within a complex drug development program. Reporting to the Head of Program Management, the responsibility of the Program Director is to drive the planning and activities required for successful execution of the endorsed asset strategy, in close partnership with the Asset Leader.

• • Management of a complex drug development program, including planning, timelines, budget oversight, proactive identification and assessment of challenges and risks, management of inefficiencies and potential resource bottlenecks and leading “lessons learned” within the program to ensure continuous improvement
  • With the Asset Leader and GPT, develop and prioritize key program objectives, go/no-go decisions and data review based on key milestones
  • Provide support where needed to GPT members on the management and delivery of projects within workstreams and the use of project management tools
  • Serve as the operational leader of the GPT, fostering collaboration, high performance and a results-orientated mindset
  • Drive the planning and execution of the integrated development plan to:
    • Set realistic yet ambitious timeframes for achieving objectives
    • Ensure program objectives and critical milestones are met to high quality, on time and within scope and budget
    • Align development plans and interdependencies with key stakeholders across nonclinical, translational, clinical, regulatory, CMC, medical affairs, and commercial
    • Closely monitor plan execution and proactively work with team members to drive completion of deliverables, manage issues and correct deficiencies
    • Chair cross functional GPT meetings, and in partnership with the Asset Leader, present program plans, progress, risks and issues to functional and senior management and governance boards

1. • Promote innovative approaches to problem solving, communicate ideas persuasively, decisively confront and resolve issues and work constructively under pressure
   • Excellent communication and interpersonal skills; collaborate sensitively and effectively with stakeholders across functions to align on priorities and make sure that interdependencies are clear
   • Embrace rapid change and ambiguity, proactively identifying opportunities for improving ways of working within the program
   • Build strong relationships with internal and external stakeholders, fostering a collaborative and inclusive work environment
   • Communicate effectively with senior leadership in a clear, concise, and confident matter

Qualifications

• Advanced degree in life sciences, engineering, or related field
• 5+ years of experience in project and program management/ leadership within the biopharmaceutical industry
• Expert knowledge of the drug development process (preferably oncology) from IND-enabling through late phase clinical development
• Proven track record of successfully driving the execution of complex projects
• Strong project management skills, with experience implementing tools and processes to streamline operations and improve efficiency. Project management certification (e.g., PMP or PRINCE2) ideal but not essential
• Demonstrated ability to thrive in a fast-paced, dynamic environment and adapt to evolving business needs

Additional Information

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

All your information will be kept confidential according to EEO guidelines.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.