Job Description

Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research laboratories. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.

The Genomics group within TMB is seeking a highly motivated and skilled candidate for the Principal Scientist position. This role is essential for developing, optimizing and deploying biomarker assays to enable clinical development at our company.

Key responsibilities will include:

• Serve as a subject matter expert in the development and validation of genomics assays collaborating with clinical and biomarker leaders, as well as operations teams, biostatistics, companion diagnostics (CDx), and regulatory affairs.
• Interface with scientists in Discovery and Clinical development to strategically plan, execute and interpret genomics results from biomarker analyses, ensuring accurate conclusions are drawn .
• Execute and coordinate the development and fit-for-purpose validation of assays within TMB Genomics lab labs.
• Execute and coordinate the analysis of clinical samples.
• Identify and assess emerging genomics technologies and validate those that have use within a clinical trial setting.
• Collaborate and liaise with external partners and Contract Research Organization (CROs) to manage the development, validation and execution of genomics assays to support all therapeutic areas.
• Write memos, final reports and publications summarizing data and present findings to clinical and other internal stakeholders.

Position Qualifications:

Education Minimum Requirement:

• Ph.D., MD or MD/PhD in a life sciences discipline (Biochemistry, Immunology, Genetics, Molecular Pathology, Cell Biology, etc.) or Chemistry

Required Experience and Skills:

• A minimum of 10 years of pharmaceutical or related experience
• A minimum of 5 years of industry experience in Genomics
• 3+ years of research experience is required with an MD
• Experience leading liquid biopsy (e.g. cfDNA, cfDNA, ctDNA, utDNA, cfDNA methylation, etc.), biomarker research, assay development and validation
• A combination of experience with various NGS platforms, qPCR, digital PCR, and other genetic/genomic assay platforms
• Understanding of standards and guidelines for analytical method validation
• Strong record of scientific achievement (publications, patents, internal/external scientific/technical presentations, etc.)
• Strong interpersonal, verbal and written communication skills
• Able to work independently, represent TMB Genomics on multiple projects
• Strong leadership skills
• Ability to execute within a matrixed organization

Preferred Experience and Skills:

• Precision medicine expertise in Oncology and/or Immunology fields
• Broad knowledge of drug development process and translational medicine
• Experience with the design and development of Minimal Residual Disease (MRD) assays, TCR/BCR repertoire sequencing and analysis is advantageous
• Molecular Genetic Pathology or Laboratory Medicine training

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

$153,800.00 - $242,200.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

04/30/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.