Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Our organizations Discovery Neuroimmunology team is seeking a highly motivated, intellectually curious postdoctoral fellow to drive innovative research aimed at defining mechanisms of neuroinflammation and microglial biology in neurodegenerative diseases. A successful candidate will independently conduct experiments to validate in vitro and in vivo models, evaluate mechanistic hypotheses and identify candidate translational biomarkers. They will also collaborate with a multidisciplinary team of scientists working to advance novel immune-based therapies for CNS diseases. The ideal candidate will have a background in neuroscience, molecular cell biology and / or immunology, the ability to flex between in vitro and in vivo model systems and have a strong interest in drug discovery.

KEY RESPONSIBILITIES

• Proactively conduct experiments to advance research objectives and collaborate across discovery teams (medicinal chemistry, pharmacology, data science) and with external academic or industry partners.

• Develop and characterize in vivo murine models of neuroinflammation and neurodegenerative pathologies such as those in Alzheimer’s and Parkinson’s disease.

• Design and execute mechanistic in vivo, in vitro, or ex vivo studies.

• Integrate and interpret data generated from transcriptomic and proteomic studies to inform translational biomarkers.

• Monitor scientific literature and incorporate new findings into project strategies.

• Communicate results clearly through internal and external presentations and scientific publications

EDUCATION

• A PhD within 6 months of hire in neuroscience, immunology, molecular cell biology or related discipline is required.

• Research experience in neurodegeneration or microglial biology is strongly preferred.

REQUIRED

• Extensive hands-on experience in developing and characterizing murine models to assess CNS biology or therapeutic intervention.

• Proficiency with murine handling, oral and injection-based dosing, blood collection and performing necropsy procedures including cardiac perfusion and brain and/or spinal cord extraction.

• Experience processing and profiling tissues using a broad range of techniques including single and/or multi-plexed immunoassays, RNA/protein analysis and immunohistochemistry.

• Proficiency in data science skills to perform processing and interpreting transcriptomic/proteomic datasets using bioinformatic tools and statistical methods.

• Creative and inquisitive mindset eager to showcase independent research leadership and apply to CNS drug discovery.

• Excellent communication skills, with the ability to effectively collaborate with cross-functional teams and present research findings both internally and externally.

• Strong publication record demonstrating research excellence in experimental design, execution, data analysis and manuscript preparation.

PREFERRED

• Experience with stereotactic intracerebral / intracerebroventricular injections or cannula implantation, sub-dissecting brain regions and / or collecting cerebrospinal fluid from mice or rats.

• Experience with CNS cell isolation, sorting and flow cytometry for transcriptomics analysis

• Experience culturing immune cell lines, primary murine microglia and iPSC-derived cells.

• Experience managing and coordinating use of transgenic mouse lines.

postdoctoralopportunities

Required Skills:

Biomarkers, Computational Biology, Data Analysis, Immunoassays, In Vivo Mouse Models, Molecular Biology, R Programming, Scientific Research, Scientific Writing, Statistical Analysis

Preferred Skills:

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

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Employee Status:

Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Not Applicable

Shift:

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Job Posting End Date:

11/24/2025

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