hero

Portfolio Careers

Discover opportunities across our network of portfolio companies.
Vertex Ventures HC
companies
Jobs

Translational Medicine Clinical Operations Immunology Therapeutic Area Lead (Prin. Scientist)

EyeBio

EyeBio

Operations
Massachusetts, USA · South San Francisco, CA, USA · West Point, PA, USA · Boston, MA, USA · Rahway, NJ, USA
USD 190,800-300,300 / year
Posted on Mar 26, 2026

Job Description

Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. We design and execute clinical pharmacology strategies spanning first-in-human studies through proof-of-biology/proof-of-concept and into late-stage development, supporting worldwide marketing applications and lifecycle management.

In a competitive external landscape and fast-paced internal environment, this position provides both strategic and operational leadership across early immunology programs, ensuring timely, high-quality execution of clinical studies and clinical pharmacology strategies worldwide. The successful candidate will telescope between strategy and hands-on execution across a portfolio of diverse modalities (e.g. peptides, small molecules, biologics), and partner cross-functionally to develop the needed expertise to successfully advance programs to key inflection points in development.

Why join us:

  • Take a leadership role at the intersection of discovery and clinical development to advance novel immunology therapeutics from bench to bedside.

  • Influence strategy, build teams, and deliver high-impact clinical programs that shape the future of patient care.

Key Responsibilities:

  • Co-own and execute the early development strategy for the immunology portfolio with the Head of TMed Immunology

  • Provide comprehensive strategic planning and operational oversight for immunology clinical programs and trials to ensure efficient, timely execution against milestones

  • Ensure appropriate resources, competencies, and partnerships are in place to meet objectives

  • Serve as the deep subject matter expert for early immunology clinical operations

  • Critically review strategy and clinical program documents (development plans, investigator’s brochures, protocols, etc.), providing scientific and operational insight to ensure best path forward

  • Partner with Business Development and Licensing to evaluate internal and external opportunities that align with portfolio strategy

  • Actively participate in annual and quarterly planning cycles: identify risks, develop and execute mitigation plans, and track performance metrics and outcomes

  • Ensure immunology data integrity across organization (Book of Business, CTMS, etc.)

  • Build and sustain strong cross-functional relationships (country operations, clinical supplies, data management, regulatory, etc.) across departments, divisions, and geographies

  • Foster the people pipeline: Attract, coach, mentor, and retain talent; provide performance management support; act as ‘player-coach’ to enrich group skillsets. Potential for people management.

  • Represent TMed on enterprise strategic initiatives and lead continuous-improvement efforts that increase program efficiency and scientific impact

  • Serve as a member of the TMed U.S. Clinical Operations leadership team and contribute to shaping department strategy

Education Requirement

  • Degree in Life Sciences with one of the following experience combinations:

  • Bachelor’s degree + 12 years related experience, OR

  • Master’s degree + 10 years related experience, OR

  • Ph.D. or doctorate +8 years related experience

  • Related Experience Includes: pharmaceutical industry roles in clinical drug development, clinical trial management, clinical site monitoring/training, medical/regulatory writing, or translational science

Required Experience and Skills

  • Proven track record building and leading high-performing cross-functional teams in a matrixed environment

  • Deep knowledge of early clinical development (Phase 1 and early proof-of-concept)

  • Demonstrated ability to collaborate, network, and influence peers, senior leaders, and external partners

  • Strong oral and written communication skills

  • Track record delivering results on firm deadlines

  • Strong decision-making skills, weighing advantages, disadvantages, and business impact for rapid decisions

  • Ability to work successfully with ambiguity and embrace uncertainty

  • Experience attracting, developing, and retaining talent

Preferred Experience and Skills

  • Experience leading clinical programs and trials for gastroenterology, dermatology, and/or rheumatology, especially autoimmune or immune-mediated disorders, including in both large and small pharma contexts

  • Familiarity with broader pharmaceutical industry considerations and trends beyond clinical development

#EligibleforERP

Required Skills:

Clinical Development, Clinical Study Design, Clinical Trial Development, Clinical Trial Management, Clinical Trials, Clinical Trials Operations, Cross-Functional Collaboration, Ethical Compliance, Ethical Standards, Immunology, Stakeholder Engagement

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The salary range for this role is

$190,800.00 - $300,300.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

No relocation

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/a

Job Posting End Date:

04/15/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.