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Vertex Ventures HC
Vertex Ventures HC

Senior Scientist, Disease Biology



South San Francisco, CA, USA
Posted on Sunday, March 3, 2024
The Company
Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company’s Native Complex™ Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables access for the first time to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with growth potential to reach many GPCRs that have been undruggable and unexploited to date. Septerna was launched by scientific founders who have made groundbreaking GPCR discoveries and by founding investor Third Rock Ventures. For more information see: www.septerna.com.
Join a multidisciplinary team of colleagues focused on creating revolutionary medicines to address significant needs of patients. Bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals, and contribute your passion, creativity, and energy to our mission. At Septerna we embrace diversity of thought, expertise, and background. We share a fearless pursuit of ground-breaking innovations, and our employees learn from each other and succeed as a team.
We are seeking an experienced scientist and dynamic scientific leader. Reporting to the Senior Director, Disease Biology, this individual will be responsible for establishing and expanding the company’s internal capabilities and be hands on running preclinical studies for programs in multiple therapeutic areas. The Senior Scientist will be responsible primarily for the development and conduct of in vivo and/or ex vivo studies in Disease Biology and Translational Sciences to support and advance Septerna’s small molecule drug discovery pipeline, working both independently and collaboratively as part of a matrixed inter-disciplinary team. The successful candidate may have the opportunity to serve as the Disease Biology lead on cross-functional project teams and to lead drug discovery programs from early discovery through IND filing.
At Septerna, we are committed to the development of meaningful therapeutics for patients with indications of high unmet need. The successful candidate will add their passion, unique talents, and expertise to a dynamic team on the frontlines of innovative therapeutic development, and help move therapies through preclinical development, positioning them for success in the clinic.
The position is based in South San Francisco, CA. Title and compensation commensurate with experience.
Key Responsibilities include but are not limited to:
· Design, execute and troubleshoot in vivo, ex vivo, and in vitro studies to inform therapeutic programs
· Generate, analyze, and interpret complex data to establish functional PK/PD relationships and elucidate the therapeutic mechanism of action of drug candidates
· Help build and expand in vivo pharmacology and biomarker discovery capabilities
· Follow all company policies/practices, and maintain accurate records and notebooks
· PhD or MSc in Diabetes or Metabolic Disorders, Endocrinology, Pharmacology, Immunology / Inflammation, or related biological science field
· At least 4 years (or 8 years with MSc) direct hands-on experience in drug discovery and development leveraging in vivo disease models in biotechnology and pharmaceutical industries
· Ability to be hands on, working in the vivarium and lab, write protocols, and execute studies
· Direct experimental experience and demonstrated expertise developing PK/PD, efficacy, and cell and tissue-based pharmacology or disease biology models
· Experience working on project teams with functional responsibility to organize, analyze, interpret, and present data
· Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
· Detail-oriented and organized, with strong interpersonal skills for clear and effective communication – ability to proactively engage and collaboration with colleagues and mentor more junior staff
· Strong preference for direct hand-on experience with in vivo diabetes or metabolic models to evaluate therapeutic effects
· Experience working with primary cells, ex vivo disease models, or in vivo species in addition to mice is a plus
· Previous work leading a program in therapeutic discovery/development
· Strong statistical analysis skills including experience analyzing large data sets and an ability to articulate conclusions and recommendations from complex study results
The anticipated salary range for candidates who will work in South San Francisco, CA is $128,000 - $145,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.