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Vertex Ventures HC
Vertex Ventures HC

Sr Associate Scientist, Cellular Immunology, Treg Biology

Sonoma BioTherapeutics

Sonoma BioTherapeutics

South San Francisco, CA, USA
Posted on Thursday, June 13, 2024

About Sonoma Biotherapeutics:

Sonoma Biotherapeutics is a South San Francisco and Seattle-based company leading the development of adoptive Treg therapies cell for autoimmune and degenerative diseases. Using next-generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. More information at www.sonomabio.com.

Job Purpose/Summary:

We are seeking an independent and motivated Senior Associate Scientist to contribute to our discovery efforts. The candidate will be part of the Treg Biology group in South San Francisco. He will be responsible for designing and conducting in vitro immunology experiments, including various molecular and cellular immunoassays to support preclinical drug development efforts. The candidate will have to present data to the discovery group as well as other Sonoma departments. The ideal candidate will bring new ideas to the table around assay development for implementing our current technology, is welcome to think outside the box, and should be motivated to apply science-based concepts into new cellular therapies. The incumbent should be independent with knowledge and expertise in cellular immunology with the initiative to dive into a fast-paced new startup. The position requires a drive to provide an exceptional hands-on work and collaborate with internal colleagues.

Roles and Responsibilities:

  • Isolate and culture immune cells from peripheral blood, biopsies, and other sample types
    Investigate phenotypes and functional statuses of immune and non-immune cells using advanced flow cytometry approaches, cytokine assays, and other methods.
  • Engineer and validate primary immune cells exhibiting predetermined characteristics, such as specificity, stability, and others, using various genetic modification techniques.
  • Collaborate with other scientists and other team members to design, execute, and troubleshoot experiments.
  • Maintain accurate documentation in form of ELN.
  • Proactively communicate data to the team and larger organization.

Qualifications and Education Requirements:

  • BA/BS in immunology, cell biology, or a related field with 6+ years relevant laboratory experience
  • Demonstrated extensive experience in flow cytometry (instrument setup and QC, troubleshooting, tissue processing and cell isolation, cell staining for surface markers, cytokines, and transcription factors, acquisition and data handling, multiparameter analysis in FlowJo, proliferation analysis) is required.
  • Demonstrated extensive experience with cytokine analysis by flow cytometry, ELISA, Luminex, and/or MSD is required.
  • Extensive experience with cell culture, preferably experience culturing primary human immune cells is required.
  • Strong communication and data presentation skills
  • Proficiency in data analysis using Prism, Excel or equivalents.
  • Ability to independently generate, analyze, interpret, and present data to a team.
  • Ability and desire to work in a fast-paced, rapidly evolving, matrixed environment.

Preferred Skills:

  • Industry experience (>2 yrs) strongly preferred.
  • Experience with gene-modification using lentiviral or similar techniques is a plus.
  • Previous experience and knowledge of IL-2 biology and regulatory T cells are a plus.

A day in the life:

A typical workday of a member of discovery group would involve work in the lab where we generate and characterize the next generation of Treg cells therapy to treat and cure patients with autoimmune disease. This work is done by a diverse and collaborative team, working all together to improve Treg cell therapies. As a member of the discovery team, you will have the opportunity to develop and foster new skills to grow in your career.

Sonoma Biotherapeutics is an Equal Opportunity Employer

At Sonoma Biotherapeutics, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.

Sonoma Biotherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. Please submit your resume along with a cover letter to careers@sonomabio.com - resumes may also be submitted without applying for a specific job.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at careers@sonomabio.com.