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Vertex Ventures HC
Vertex Ventures HC

Senior Research Associate, Research Operations

Matchpoint Therapeutics

Matchpoint Therapeutics

Watertown, MA, USA
Posted on Friday, April 26, 2024

Matchpoint is a biotechnology company harnessing the power of covalency to discover precision covalent medicines to transform the treatment of immune diseases and other serious illnesses. The company's proprietary Advanced Covalent Exploration (ACE) platform integrates advanced chemoproteomics, machine learning and covalent chemistry library evolution. Matchpoint has an emerging pipeline of novel covalent medicines initially focused on immunology.

Founded in 2021 by Atlas Venture and Access Biotechnology together with leading scientists from the Dana Farber Cancer Institute and Stanford, we are rapidly growing our team and looking for passionate, driven, and creative thinkers to join us in ushering in a new era of covalent medicines.

Position Summary

We are seeking a highly motivated Senior Research Associate to join our Research Operations team, supporting assay execution, compound management, and lab automation. The ideal candidate possesses a strong scientific background and a positive attitude for learning and facilitating research.

This position will focus on assay development, troubleshooting, and routine execution of in-vitro biochemical and cellular assays to support drug discovery programs. The candidate will also support activities in compound management involving preparing compound stocks, compound quality control, and operating automation tools like Hamilton Verso, Beckman Echo-Access platform, and other liquid handlers.

The suitable candidate will have a successful track record of working cross-functionally as a member of drug discovery teams, as well as through a matrix organization. Excellent written and oral communication skills are preferable, as is the desire and ability to work in a multidisciplinary, fast paced, and science-focused environment.

Key Responsibilities

  • Perform biochemical and cellular studies of drug potency
  • Analyze and interpret quantitative data
  • Effectively conduct and organize activities, and communicate results through oral and written presentations
  • Read and apply relevant scientific literature
  • Operate lab automation tools including liquid handlers and automated pipettes to support compound management activities and increase assay throughput
  • Assay development and transfer to internal and external teams for screening and compound characterization
  • Participate in compound management activities including, but not limited to, compound receipt, inventory management, cherry-picking, solvating, plating, etc.
  • Clear written and verbal communication of results to project teams and research leadership
  • Contribute to scientific discussions within project teams
  • Timely maintenance of an accurate electronic notebook with data interpretation


  • BS or MS in Biochemistry, Molecular Biology, Cell Biology, or a related discipline with 3+ years of relevant lab experience
  • Experience with biochemical or cellular assays is required
  • Hands on experience with lab automation systems
  • Familiarity working with software systems, spreadsheets, and working with large data sets
  • Exposure to spreadsheets and curve-fitting programs is preferred
  • Highly motivated, detail-oriented, curious of the science, and desiring to learn novel in vitro assay techniques
  • Candidate must be highly collaborative and thrive in a dynamic, multi-disciplinary environment
  • Strong organizational, communication, and interpersonal skills

We offer a competitive compensation package, including equity-based compensation, annual bonus potential, healthcare benefits, 401(k), parking, and flexible paid time-off.

Matchpoint is an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, marital or veteran status, disability, or any other legally protected status.