Our Opportunity…

We’re looking for a highly motivated Associate Scientist with a background in viral vector analytical development to help drive the development of our cell therapy products. As member of our Technical Operations department you will be a vital part of a highly collaborative team working to achieve Obsidian’s vision by translating innovative science into medical breakthroughs for patients, starting with our lead program OBX-115, a novel engineered tumor-infiltrating lymphocyte (TIL) therapy.

This is a unique opportunity to be a contributor in a well-funded clinical company with blue chip investors, field-leading advisors, best-in-class partners, and an experienced team. You'll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.

This is an onsite role located in our Bedford office.

You will…

• Learn and execute analytical methods to support characterization studies of Viral Vector starting materials and cell therapy products.
• Help design and execute experiments in collaboration with process development team to support critical material characterization.
• Author and review technical documents and data presentation including, but not limited to, study protocols, reports, and test methods.
• Maintain excellent records of experiments, including Electronic Notebook .
• Collaborate effectively across the Obsidian organization.
• Present internally to project teams, management, and scientific teams.
• Perform assigned work independently following established procedures with limited direction.

You bring…

Core Qualifications

• MS with 2+ or BS with 4+ years of relevant industry experience (degree in a relevant field such as biochemistry, cell biology, engineering, immunology).
• Excellent aseptic techniques and experience in product release and characterization methods with a focus on cell-based assays including cell-based titer assays, vector potency assays and molecular and immunoassays (PCR / qPCR, ddPCR, ELISA and MSD).
• Excellent organizational and documentation skills with the ability to communicate and prioritize effectively to deliver results within established timelines.
• Effective organization and record-keeping skills, including an ability to manage multiple responsibilities in parallel.
• Self-motivation and a proven ability to work autonomously with general direction to meet objectives and timelines.
• Excellent oral, written, and visual communication skills. You listen to understand and communicate effectively and persuasively with partners, colleagues, and leadership.
• Scientifically rigorous in designing and executing experiments, and record keeping.
• Collaborative and accountable – recognizes success requires teamwork and interdisciplinary thinking; shares feedback and ideas to facilitate better outcomes
• Self-motivated, with a proven ability to meet objectives and timelines, managing multiple responsibilities in parallel.
• Flexible - adapts to change in a fast paced, rapidly developing environment
• Curious and humble – seeks and welcomes input/expertise of others, continuous learner
• Tenacious and resilient – is not easily overwhelmed by challenges, delivers on commitments

Bonus Qualifications

• Experience with multi-parameter flow cytometry assays
• Demonstrated track record with analytical development supporting late-stage development of cell therapies or biologics.
• Experience with analytical assay technical transfer and/ or qualification.
• Experience working in a QC laboratory